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International Conference on Environmental
Epidemiology & Exposure
2 > 6 September 2006, la Villette
Conference Centre, Paris
Sunday Sept. 3, 2006 - 7.30-8.30
Monday 4 September, 2006 - 7.30-8.30
Tuesday 5 September, 2006 - 7.30-8.30
Sunday Sept. 3, 2006 - 7.30-8.30
SETI : developing exposure assessment techniques for unique subpopulations
Elisabeth Dederick
Description : This course is designed to introduce the concept of unique exposure scenarios and their relevance to exposure assessment models. Participants will become familiar with a methodology for characterizing activities that may present exposure scenarios to unique subpopulations. A case study of Native American artisan activities will be used for teaching purposes. The presenter will lead a discussion on the relevance of enhanced exposure assessment tools to risk policy, risk management and risk communication strategies.
Course Aims :
SET2: Prevention based on policy or risk? Case study of the endocrine disruptor Atrazine
Pamela Shubat and Jean Johnson
Description : The course participant will 1) become familiar with current toxicologic and epidemiologic data on Atrazine exposure and health effects; 2) Identify areas of scientific uncertainty for Atrazine health effects; and 3) Discuss the ways in which uncertainty may be addressed through policies of precaution and risk-based regulation
Course content: Atrazine is one of the most highly used herbicides in the USA. It is used to control broadleaf and grassy weeds in food crops and other agriculture. Atrazine and its environmental breakdown products have been found in groundwater in the Midwest states, leading to a need for continual evaluation of drinking water standards to protect public health. Despite the extensive toxicological data and growing body of epidemiological data on Atrazine, there are many questions concerning low-level exposures, the timing of these exposures, and most importantly, the interpretation of the studies for human populations.
In this course, participants will review the database of studies used for human health risk assessment; the rationale for selection of references doses and uncertainty and variability factors; and consider the evidence for carcinogenicity. Intriguing toxicological data gaps will be presented, particularly related to endocrine changes and development, and contrasted with what has been observed in epidemiology. The resulting human health risk values (standards) for drinking water quality will be presented.
Participants will also consider the controversy over precaution versus risk-based policies for protecting public health and discuss the special interests that have a stake in the outcome. Participants discuss the policy actions in European countries and contrast those with the debates taking place in the US. Participants will discuss the implications of moving policy discussions from the national level to the state and local level as advocacy groups seek a receptive audience for precaution-based rules.
Credentials: The two presenters, both researchers from the Minnesota Department of Health, are Pamela Shubat and Jean Johnson.
Dr. Shubat holds a Ph.D. in pharmacology and toxicology from the University of Arizona. She has worked in the field of toxicology and risk assessment for 21 years. She has led work in risk assessment for fish contaminants, program development for community environmental assessments, and incorporating children’s exposure and toxicologic sensitivity into risk assessment of water exposures. Dr. Shubat is currently involved in developing a water quality standard for Atrazine for the state of Minnesota. She is an adjunct faculty member of the University of Minnesota, Minneapolis, MN, USA.
Dr. Johnson holds a Ph.D. in Environmental Health with an emphasis in epidemiology from the University of Minnesota. She has worked in the field of environmental and occupational health for over 20 years. As an environmental epidemiologist for the State, she has studied community health and conducted risk communication in relation to environmental exposures, including pesticides, arsenic and nitrate contaminants in drinking water, dioxins in soils, and tremolite asbestos. She is an adjunct faculty member of the University of Minnesota, Minneapolis, MN, USA.
Monday 4 September, 2006 - 7.30-8.30
MET1: Recent developments in allergen avoidance
Professor Denis Charpin
Background: There have been many studies and meta-analysis devoted to avoidance of indoor allergens.
Aims: To review the available evidence and know future research directions
Content:
MET2: Grant-writing workshop
Richard Clapp
Description : This workshop will present some outlines of successful applications for grant support for environmental epidemiology research. Participants will break into small groups and develop an idea for a proposal, working with an experienced researcher and ISEE member. They will follow the steps on sample application forms handed out to each group. Then, the small groups will present their proposed application to the entire group for discussion and critique. The aims and objectives are to provide participants with guidance and experience in beginning to develop research grant proposals to submit to various funding agencies.
MET3: Funding Opportunities for Collaborative Research from the Fogarty International Center of the US National Institutes of Health
Co-Chair: Christopher Schonwalder (Research Triangle Park, USA)
Tuesday 5 September, 2006 - 7.30-8.30
TET1: European Commission-sponsored research in the field of environmental epidemiology: past achievements and future possibilities : Overview of FP6 Projects and information of FP 7
Tuomo Karjalainen
Description : Give an overview of the projects they have funded, and especially talk about the 7th framework programme (2006-2013) in which significant amounts of money will be available for epidemiological and exposure research.
The aim of the session is to:
TET2: Manuscript-writing workshop
Richard Clapp
Description : Participants will be presented with an outline of the elements of a successful manuscript published in an international journal. Workshop leaders are experienced editors with extensive publications they have authored or co-authored. Participants will break into small groups and discuss a potential manuscript from their own work and will outline how this would be developed for submission to a journal. They will work with experienced workshop leaders in the small groups, and then present their ideas to the full group for discussion and critique. The aims and objectives of the workshop are to give participants guidance in how to write manuscripts. In addition, Dr. Robbins will explain a developing “mentoring” program called AuthorAID where senior scientists from developed countries assist colleagues from developing countries with less experience.
TET3: Production and use of mycotoxins uniformly enriched with stable isotope for their dosage in biological samples
Doctor Marcel Delaforge
Description :
Pharmacological studies of exogenous compounds often encounter problems: these compounds are in such infinitesimal amount in their biological matrices, that they require particular detection method. This is classically done by using radio-labeled compounds and HPLC-MSn techniques. The use of stable isotopes is an interesting alternative for in vitro and in vivo studies including human.
In order to prepare 13C,15N-enriched mixture of mycotoxins or drugs of natural origin, we developed a strategy consisting of: i) plant growth in the presence of 10% 13CO2 as the only source of carbon, and in the presence of 15N-enriched nitrogen sources. The whole plant uniformly incorporates 15N and 10% 13C during photosynthesis; ii) solid culture on host labeled plant of different filamentous fungi or bacteria producing various drugs or mycotoxins; iii) pharmacological studies of the drug obtained and the mycotoxin, either isolated or in its natural environment.
As an example, growth of Fusarium graminearum on 13C wheat seeds for 10 to 30 days allowed to produce 13C-labeled zearalenone, which was used for metabolism and transport studies. The metabolic profile is the same than the one obtained from commercial zearalenone. The isotopic pattern makes metabolite detection easier, and identification can be made from both MS and MSn spectra including those resulting from cleavage or conjugation. In addition such isotopic pattern is used for quantitative evaluation of transport across biological membranes. Such compound can also be used as internal standard with high reliability in order to quantify zearalenone in contaminated food samples.
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